PE-22-28 10mg
PE-22-28 is a synthetic peptide derived from spadin, a natural TREK-1 potassium channel blocker. Research demonstrates rapid antidepressant-like effects through TREK-1 channel inhibition, increased hippocampal neurogenesis, and enhanced serotonergic neurotransmission. It produces antidepressant effects within days rather than weeks.
Sequence
Ac-Asp-Gly-Gly-Leu-Gly-Gly-Gln (modified spadin fragment)
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Volume pricing
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Certificate of Analysis
Independently verified by Janoshik Analytical
Test ID
JAN-PE2228-2026-001
Purity
98.7%
Method
HPLC-MS
Batch
PE2228-2026-01A
Test Date
February 1, 2026
Identity
Confirmed
Storage Requirements
Lyophilized
2-8°C, protect from light
Reconstituted
2-8°C, use within 21 days
TREK-1 channel blocker. Reconstitute with bacteriostatic water.
Published Research
1 peer-reviewed studies
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design
Mazella J, Petrault O, Lucas G, et al. — PLoS Biology, 2010
Discovery of spadin-derived peptides as rapid-acting antidepressants via TREK-1 inhibition.
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Research use only. All products are sold strictly for in-vitro research purposes only. Not for human consumption. Information provided references published research literature. No medical claims are made or implied.